Cardinals Struggle Against Lefties, Orioles Look to Capitalize

Orioles vs Cardinals Prediction Odds

Pick: Orioles ML -134

The Baltimore Orioles and St. Louis Cardinals will face off on Wednesday, May 21, in a matchup that could have major implications for the AL East and NL Central divisions. The Cardinals have struggled mightily against left-handed pitchers this season, batting just .215 with a .633 OPS. The Orioles, on the other hand, have a left-handed-heavy lineup that features Trey Mancini, Anthony Santander, and Ryan Mountcastle. The Orioles have been one of the hottest teams in baseball since the start of May, and they will be looking to continue their winning ways against the Cardinals. The Orioles are 12-5 in their last 17 games, and they have won four of their last five series. The Cardinals, on the other hand, have been struggling lately. They have lost four of their last six games, and they are just 5-10 in their last 15. The Orioles are the clear favorites in this matchup, and they should be considered a good bet to win at home. The Orioles are -134 favorites on the moneyline, while the Cardinals are +114 underdogs.